Increasingly Powerful Opioid Antagonists Are Not Necessary

In the U.S., drug overdose deaths have increased substantially during the COVID-19 pandemic. Synthetic opioids are implicated as the primary drivers of this increase. Naloxone is recommended for use and distribution by health professionals and laypersons to address this crisis. Given the relative potency of many synthetic opioids, it has been theorized that higher doses of naloxone may be required to effectively reverse overdoses. This study tests that theory and provides recommendations related to naloxone prescriptions.

Source: International Journal of Drug Policy